Arterial Pressure and Renal Function in Two-Kidney, One Clip Goldblatt Hypertensive Rats Maintained on a High-Salt Intake
作者:
Cynthia Ann Jackson,
L Gabriel Navar,
期刊:
Journal of Hypertension
(OVID Available online 1986)
卷期:
Volume 4,
issue 2
页码: 215-221
ISSN:0263-6352
年代: 1986
出版商: OVID
关键词: Sodium chloride;two-kidney;one clip Goldblatt hypertension;plasma renin activity;kidney renin content;renal function
数据来源: OVID
摘要:
Arterial blood pressure and renal function of both clipped and non-clipped kidneys of benign two-kidney, one clip (2K1C) Goldblatt hypertension were evaluated in order to determine whether high-salt intake alters the course of the development and magnitude of hypertension or influences renal function. The administration of 0.9% sodium chloride as a drinking solution for 3 weeks suppressed plasma renin activity (PRA) and kidney renin content of the clipped kidney to normal values. Despite suppression of PRA and kidney renin content, the saline-drinking clipped rats still developed hypertension of the same magnitude as the water-drinking clipped rats. However, the onset of hypertension was delayed by 4 days. Urine flow, glomerular filtration rate (GFR) and sodium excretion rate from the clipped kidneys of the saline-drinking clipped rats were higher than the corresponding values in the water-drinking rats, and approached those observed in control animals. Thus, the high-salt intake which was associated with suppression of the activity of the renin-angiotensin system delayed the onset of, but not the final magnitude of, the hypertension. In addition, kidney function in the clipped kidneys of saline-drinking clipped rats was enhanced compared with that observed in the water-drinking clipped rats.
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