The occurrence of venous air embolism (VAE) during neurosurgery in the sitting position is well documented. The optimal position of an air aspiration catheter appears to be with the catheter tip at the junction of the right atrium and superior vena cava (SVC). A number of localization techniques have been described, with the electrocardiographic guided technique being the most commonly employed. This case report describes the use of transesophageal echocardiography (TEE) for the precise and timely placement of a right atrial-SVC air aspiration catheter.