Calcium Antagonists for Uterine Relaxation
作者:
W. Lechner,
Ch. Marth,
F. Keene,
期刊:
Gynecologic and Obstetric Investigation
(Karger Available online 1989)
卷期:
Volume 28,
issue 3
页码: 144-146
ISSN:0378-7346
年代: 1989
DOI:10.1159/000293551
出版商: S. Karger AG
关键词: Uterine relaxation;Calcium antagonism
数据来源: Karger
摘要:
The uterus-relaxant effect of diltiazem, a recently developed calcium antagonist, was investigated in vitro. 24 myometrial strips dissected from the lower uterine segment during cesarean section showed a statistically highly significant (p < 0.001) decrease of their spontaneous contractility in the presence of Diltiazem 10––6M: 82% after 10 min, 100% after 20 and 100% after 60 min (median values). Diltiazem, which is considered to be the most balanced calcium antagonist as far as cardiovascular side effects are concerned, could be of considerable interest also for clinical use.
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