BALANCING THE IMMUNE SYSTEM FOR TOLERANCEA Case for Regulatory CD4 Cells1
作者:
Field2,3,4,
Elizabeth Gao4,
Qinglin Chen4,5,
NaiXi Rouse2,
期刊:
Transplantation
(OVID Available online 1997)
卷期:
Volume 64,
issue 1
页码: 1-7
ISSN:0041-1337
年代: 1997
出版商: OVID
数据来源: OVID
摘要:
In the past, tolerance mechanisms have focused on processes that involve elimination (deletion) or paralysis (anergy) of immune responses. It is now becoming clearer that peripheral tolerance to antigen depends on the generation of regulatory cells that function to maintain the tolerant state. The development of peripheral tolerance may require that the immune system utilize several strategies, including deletion, anergy, and immunoregulatory pathways, and these strategies may overlap. Recent investigations using animal models of transplantation tolerance have demonstrated that immunoregulatory CD4 mechanisms may play a central role in limiting organ-destructive immune responses. In this Overview, we discuss the rationale behind the need for invoking active regulatory mechanisms in peripheral immunologic tolerance and summarize the data that support or refute a CD4 regulatory mechanism.
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