DNA Flow Cytometry in the Prognosis of Primary Malignant Melanoma
作者:
Detlef Bartkowiak,
Johannes Schumann,
Friedrich J. Otto,
Andrea Lippold,
Hubert Drepper,
期刊:
Oncology
(Karger Available online 1991)
卷期:
Volume 48,
issue 1
页码: 39-43
ISSN:0030-2414
年代: 1991
DOI:10.1159/000226892
出版商: S. Karger AG
关键词: Ploidy;DNA index;S phase;Melanoma;Prognosis;Flow cytometry
数据来源: Karger
摘要:
DNA flow cytometry was carried out on 804 primary melanomas. The data were analyzed with a follow-up of 24–96 months. 57% of the cases were diploid, 32% had one abnormal cell population, and 11% were multiclonal. In 8% of the aneuploid tumors there were cell lines in the hypertetraploid range. A reliable S phase determination was possible in 524 cases. Among these 11 % had an S phase exceeding 15%. Using an increased tumor thickness, relapse rate and mortality as criteria of tumor progression, aneuploidy and multiclonality, the occurrence of hypertetraploid cell lines and a high S phase ( > 15%) proved to be correlated with a poor prognosis.
点击下载:
PDF
(1657KB)
返 回