Studies on the neuroexcitotoxin β‐N‐oxalo‐L‐α, β‐diaminopropionic acid and its isomer α‐N‐oxalo‐L‐α, βdiaminopropionic acid from the root of Panax species
作者:
YI‐CHENG LONG,
YUN‐HCA YE,
QI‐YI XING,
期刊:
International Journal of Peptide and Protein Research
(WILEY Available online 1996)
卷期:
Volume 47,
issue 1‐2
页码: 42-46
ISSN:0367-8377
年代: 1996
DOI:10.1111/j.1399-3011.1996.tb00808.x
出版商: Blackwell Publishing Ltd
关键词: β‐N‐oxalo‐L‐α;β‐diaminopropiopionic acid;α‐N‐oxalo‐L‐αβ‐diaminopropionic acid;interconversion;Panax species;neuroexcitotoxin;physical constants
数据来源: WILEY
摘要:
The neuroexcitotoxic nonprotein amino acid, β‐N‐oxalo‐L‐α, β‐diaminopropionic acid (β‐N‐ODAP) was found in Panax species such as Panax ginseng C.A. Meyer’(cultivated in Northeastern China),Panax quinquefolius(L), Panax notoginseng ‘F.H. Chen’(cultivated in Southwestern China), Korean red ginseng and Jilin (China) red ginseng. β‐N‐ODAP was verified to be a natural substance, and its isomer α‐N‐oxalo‐L‐α, β‐diaminopropionic acid (α‐N‐ODAP) is very likely an artifact generated during the separation process. The interconversion between β‐N‐ODAP and α‐N‐ODAP was observed. Results showed that both β‐N‐ODAP and α‐N‐ODAP can easily be converted into their isomers at higher temperature or in acidic and basic solution. Their interconversion equilibrium constant and rate constants were obtained. Upon extensive study and a good understanding of the interconversion, accurate physical constants and spectroscopic dat
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