Hyperplasia of Antral G Cells in Uraemic Patients
作者:
F. Carlei,
U. Caruso,
E. Lezoche,
G. Ruscitto,
P. Lackie,
U. Casciani,
V. Speranza,
J.M. Polak,
期刊:
Digestion
(Karger Available online 1984)
卷期:
Volume 29,
issue 1
页码: 26-30
ISSN:0012-2823
年代: 1984
DOI:10.1159/000199004
出版商: S. Karger AG
关键词: Gastrin;Gastritis;Immunocytochemistry;Quantification;Uraemia
数据来源: Karger
摘要:
In this study we have performed a quantitative analysis of antral gastrin cells in 9 uraemic patients under dialytic treatment compared to a group of 10 chronic gastritis patients with a similar histological degree of gastritis. Immunocytochemistry was carried out on endoscopic biopsies of both groups. Using a computerised image analysing system we showed a significant increase of G-cell density (number of cells/mm2) in uraemic patients compared to non-uraemics (p < 0.001). These findings provide a further morphological basis for the elevation of gastrin levels in chronic uraemic patients, suggesting the existence of a specific factor inducing G-cell proliferation in these patients.
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