Recent advances concerning the function and regulation of the facilitative and sodium-dependent glucose transport proteins are discussed. Physiologic roles have been proposed for GLUT3 and CLUT5 in the brain and intestine, respectively. Cell biologists are beginning to elucidate the subcellular trafficking pathways of GLUT4 in insulin-responsive cells. New members of the SGLT family, including a sodium-nucleoside cotransporter, have been identified.