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Wet Disc Testing of Mafenide Hydrochloride, Chlorhexidine Gluconate, and Triple Antibio...
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Wet Disc Testing of Mafenide Hydrochloride, Chlorhexidine Gluconate, and Triple Antibiotic Solution Against Bacteria Isolated from Burn Wounds
作者:
Ian Holder,
期刊:
Journal of Burn Care & Rehabilitation
(OVID Available online 1990)
卷期:
Volume 11,
issue 4
页码: 301-304
ISSN:0273-8481
年代: 1990
出版商: OVID
数据来源: OVID
摘要:
Various antimicrobial solutions for topical use on burn wounds tested, in vitro with a newly described wet disc assay, for their activity against bacterial isolates from patients with burns. The antimicrobial activity of triple antibiotic solution was shown to reside in the neomycin component. The activity of 2.5% mafenide hydrochloride solution was equal to that of 4% mafenide HCl and could be used clinically with significant savings and perhaps, fewer side effects. Chlorhexidine gluconate had broad antimicrobial activity in an 0.05% solution in water; however, dissolving the active ingredient in saline nullified its activity significantly. The wet disc assay appears to be a useful means by which to assess the efficacy of solutions for topical use.
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