Renotropic Factor(s) in Plasma from Uninephrectomized Rats
作者:
H.G. Preuss,
Eva F. Terryi,
A.I. Keller,
期刊:
Nephron
(Karger Available online 1970)
卷期:
Volume 7,
issue 5
页码: 459-470
ISSN:1660-8151
年代: 1970
DOI:10.1159/000179845
出版商: S. Karger AG
数据来源: Karger
摘要:
The nature of the stimulus(i) that initiates renal hypertrophy and hyperplasia is unknown. This investigation assays plasma of uninephrectomized rats for activity of renotropin(s), a humoral factor(s) which has been postulated to control compensatory renal growth. Plasma taken from rats 24 hours after uninephrectomy when compared to plasma taken from sham operated animals stimulates thymidine incorporation into DNA and uridine incorporation into RNA in kidney slices but not in liver slices. Stimulation is not seen in plasma from bilaterally nephrectomized rats. It is concluded that the assay described shows the presence of a circulating renal growth factor which is probably produced in response to a decrease in renal mass.
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