Linkage Analysis of the D1 Dopamine Receptor Gene and Manic Depression in Six Families
作者:
S. Jensen,
R. Plaetke,
J. Holik,
M. Hoff,
P. O’Connell,
F. Reimherr,
P. Wender,
Q.Y. Zhou,
O. Civelli,
M. Litt,
M. Leppert,
W. Byerley,
期刊:
Human Heredity
(Karger Available online 1992)
卷期:
Volume 42,
issue 5
页码: 269-275
ISSN:0001-5652
年代: 1992
DOI:10.1159/000154081
出版商: S. Karger AG
关键词: Manic depression;Linkage analysis;Dl dopamine receptor
数据来源: Karger
摘要:
Disturbances in dopaminergic activity may play an important role in the pathogenesis of manic depression. The effects of dopamine are mediated by at least five G protein coupled receptors, D1, D2, D3, D4 and D5. Recently, three separate research groups have cloned and characterized the D1 dopamine receptor, which localizes to 5q35.1. We undertook a linkage analysis between the Dl receptor polymorphisms and manic depression in six families in which segregation of the disease was consistent with autosomal dominant inheritance. A highly polymorphic flanking DNA marker, CRI-L1200, was also analyzed as the D1 gene RFLPs were relatively uninformative in our families. Multipoint analyses of manic depression and these DNA markers resulted in lod scores of less than –3.0 at the D1 locus, indicating that the Dl dopamine receptor gene does not confer an inherited susceptibility to manic-depressive illness in the families studie
点击下载:
PDF
(1121KB)
返 回