首页   按字顺浏览 期刊浏览 卷期浏览 Constriction of the Fetal Ductus Arteriosus by Glucocorticoid Hormones
Constriction of the Fetal Ductus Arteriosus by Glucocorticoid Hormones

 

作者: KAZUO MOMMA,   SHIGETAKE NISHIHARA,   YACHIO OTA,  

 

期刊: Pediatric Research  (OVID Available online 1981)
卷期: Volume 15, issue 1  

页码: 19-21

 

ISSN:0031-3998

 

年代: 1981

 

出版商: OVID

 

数据来源: OVID

 

摘要:

Hydrocortisone, prednisolone, and betamethasone were injected into a rat that was 21 days pregnant, and the fetal ductus arteriosus was studied using the rapid whole-body freezing technique. All these glucocorticoids constricted the fetal ductus arteriosus in a dose-dependent relationship. Fetal ductal constriction was maximum 1 to 4 hr after injection and was significantly more prominent in premature fetuses than in mature ones.SpeculationGlucocorticoids may be useful in constricting the patent ductus arteriosus in the premature babies in place of indomethacin, which is contraindicated in the presence of renal failure or jaundice. Administration of glucocorticoids to the mother may cause fetal ductal constriction and fetal distress.

 

点击下载:  PDF (253KB)



返 回