A statistical assessment of the quantitative uptake of vinyl chloride monomer from aqueous solution
作者:
JimR. Withey,
BrianT. Collins,
期刊:
Journal of Toxicology and Environmental Health
(Taylor Available online 1976)
卷期:
Volume 2,
issue 2
页码: 311-321
ISSN:0098-4108
年代: 1976
DOI:10.1080/15287397609529435
出版商: Taylor & Francis Group
数据来源: Taylor
摘要:
The presence of vinyl chloride monomer (VCM) in foodstuffs and its demonstrated carcinogenic potential when administered by the oral route has raised questions concerning the quantitative estimation of the safety of the use of food packaging fabricated from rigid polyvinyl chloride. A statistical model, which was tested by curve‐fitting data obtained from an oral uptake study, has been demonstrated to be of predictive value. Ninety‐five percent confidence limits were also calculated, and the data from this study were compared with those from a previous gas phase exposure study. It was concluded that if the total daily liquid intake contained 20 ppm of VCM then the area generated under the blood level‐time curve, for rats, would be equivalent to an inhalation exposure of about 2 ppm for 24 hr.
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