Determination of Ranitidine Hydrochloride in Pharmaceutical Preparations by Ultraviolet and Visible Spectrophotometry
作者:
ElianeMaria de Almeida Orsine,
JorgeLuiz Seferin Martins,
期刊:
Analytical Letters
(Taylor Available online 1993)
卷期:
Volume 26,
issue 9
页码: 1933-1941
ISSN:0003-2719
年代: 1993
DOI:10.1080/00032719308017441
出版商: Taylor & Francis Group
关键词: Ranitidine hydrochloride;Ultraviolet spectrophotometry;Visible spectrophotometry;Pharmaceutical preparations
数据来源: Taylor
摘要:
Ranitidine hydrochloride in tablets (T) and injections (I) was determined by ultraviolet spectrophotometry (UVS) at 313 nm and visible spectrophotometry (VISS) at 615 nm, after reaction with 3-methyl-2-benzothiazolinone hydrazone hydrochloride (MBTH) and ferric chloride. For UVS, Beer's law was obeyed in the range 5.0 – 18.0 μg/mL. The coefficients of variation (CV) for the samples T were 0.36% and 0.71% and for the samples I were 0.51% and 0.24%. The recovery average (RA) was 99.88%. For UVS, Beer's law was observed in the range 1.44 – 5.76 μg/mL. The CV for T were 0.72% and 0.59%, and for I were 0.53% and 0.61%. The RA was 99.39%. The precision and accuracy of the two methods were compared.
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