Oral Acanthosis NigricansReport of a Case and Comparison of Oral and Cutaneous Pathology
作者:
J. Hall,
Adele Moreland,
Gregory Cox,
Thomas Wade,
Brad Neville,
期刊:
The American Journal of Dermatopathology
(OVID Available online 1988)
卷期:
Volume 10,
issue 1
页码: 68-73
ISSN:0193-1091
年代: 1988
出版商: OVID
关键词: Acanthosis nigricans;Oral acanthosis nigricans;Malignant acanthosis nigricans;Cutaneous acanthosis nigricans;Gastric adenocarcinoma
数据来源: OVID
摘要:
Malignant acanthosis nigricans is usually associated with adenocarcinomas of the digestive tract. The lesions of acanthosis nigricans commonly run a parallel course to the associated malignancy, producing hyperpigmented, roughened plaques on the skin and, sometimes, verrucalike papules on the oral mucosa. The clinical differences between cutaneous and oral acanthosis nigricans are mirrored by the marked differences in the histopathology. Because oral acanthosis nigricans is uncommon, recognizing histologic features may be difficult. The oral lesions have a true acanthosis and epithelial papillary hyperplasia while the cutaneous forms show slight irregular acanthosis that alternates with areas of epidermal atrophy and dermal papillomatosis.
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