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Thoracoabdominal Wall Repair with Glutaraldehyde-Preserved Bovine Pericardium

 

作者: SantillanPatricio,   JassoRogelio,   SotresAvelina,   OlmosRaul,   ArreolaJose Luis,   GarciaDavid,   VandaBeatriz,   GaxiolaMiguel,   SantibañezAlfredo,   MartinSalvador,   CabelloRicardo,  

 

期刊: Journal of Investigative Surgery  (Taylor Available online 1996)
卷期: Volume 9, issue 1  

页码: 45-55

 

ISSN:0894-1939

 

年代: 1996

 

DOI:10.3109/08941939609012459

 

出版商: Taylor&Francis

 

关键词: hernia;chest wall;diaphragm;reconstruction;pericardium;glutaraldehyde

 

数据来源: Taylor

 

摘要:

Glutaraldehyde-preserved bovine pericardium (GPBP) is evaluated as a bioprosthesis for the reconstruction of surgical defects in the thoracoabdominal wall. The mechanical properties of bovine pericardium preserved at different concentrations of glutaraldehyde were studied. Samples preserved in 0.5% glutaraldehyde showed a significantly higher tensile strength (11.7±0.8 N/mm2) than samples preserved in 2.5, 5, or 10% (similar to pericardium preserved in normal saline). The percentage of elongation was significantly lower than samples preserved in 1, 2.5, and 5% glutaraldehyde. GPBP at 0.5% was used to repair experimentally induced defects of the abdominal wall (n = 9), chest wall (n = 6), diaphragm (n = 6), and sternum (n = 7). All animals presented adequate tolerance to the material used and no case of infection or rejection of the material was seen in any of the animals. Finally, 0.5% GPBP was used clinically in a series of 40 patients: postincisional abdominal hernia (n = 30), inguinal hernia (n = 8), diaphragmatic hernia (n = I), and congenital pelvic defect with prolapse of abdominal organs (n = 1). Surgical use showed that GPBP was a very manageable material and long-term results were good in 37patients with a mean follow up of 18 months (range 5-35 months). Six patients presented seroma formation (all abdominal hernia patients), three of which eventually developed infection and had the GPBP patch removed at 3, 5, and 7 months postoperatively. The rest of the patients presented good scar formation with adequate resistance at the area of implantation. GPBP is a biological material with sufficient resistance to be used surgically in the repair of thoracoabdominal defects. Ideal concentration of glutaraldehyde to be used in the preparation–preservation of the material is 0.5% since higher concentrations negatively affect its tensile rupture strength and elongation.

 

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