Pharmacokinetic Comparison of Two Albendazole Dosage Regimens in Patients with Neurocysticercosis
作者:
M. Sánchez,
R. Suástegui,
D. González-Esquivel,
J. Sotelo,
H. Jung,
期刊:
Clinical Neuropharmacology
(OVID Available online 1993)
卷期:
Volume 16,
issue 1
页码: 77-82
ISSN:0362-5664
年代: 1993
出版商: OVID
关键词: Neurocysticercosis;Dosage regimen;Albendazole
数据来源: OVID
摘要:
SummaryTo evaluate two different dosage regimens for albendazole (7.5 mg/ kg twice a day or 5.0 mg/kg three times a day), a study was performed in 10 patients with a diagnosis of parenchymal brain cysticercosis. Each patient received both regimens sequentially according to a randomized, crossover design. Blood and urine samples were taken once the drug steady state had been reached. Plasma levels of albendazole sulfoxide at steady state were determined using a HPLC method. In spite of a great intersubject variability observed with both regimens in the area under the curve (AUC) and in the minimum steady-state plasma concentration (Cp min ss), no statistically significant differences were found in these parameters. We suggest that a regimen of 7.5 mg/kg every 12 h can favorably replace the currently used regimen of 5 mg/kg every 8 h.
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