Cardiovascular Abnormalities in Osteogenesis Imperfecta
作者:
Modestino Criscitiello,
James Ronan,
Edwin Besterman,
William Schoenwetter,
期刊:
Circulation
(OVID Available online 1965)
卷期:
Volume 31,
issue 2
页码: 255-262
ISSN:0009-7322
年代: 1965
出版商: OVID
数据来源: OVID
摘要:
Three adults with osteogenesis imperfecta and associated cardiovascular lesions are reported. Two presented with aortic insufficiency due to dilatation of the aortic root for which none of the usual causes is apparent. The third patient was found to have lesions involving pulmonary, aortic, and mitral valves in addition to microscopic changes in the pulmonary artery and aorta. It is suggested that in osteogenesis imperfecta, as in other heritable disorders of connective tissue, cardiovascular defects may become apparent after the passage of time and play a dominant role in the natural history of the disease process.
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