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Application of carboxylic‐phospholanic mixed anhydrides to fragment coupling in peptide synthesis

 

作者: CONSTANTINE POULOS,   CHRIS P. ASHTON,   JEREMY GREEN,   OLUYINKA M. OGUNJOBI,   ROBERT RAMAGE,   THEODOROS TSEGENIDIS,  

 

期刊: International Journal of Peptide and Protein Research  （WILEY Available online 1992）
卷期: Volume 40, issue 3‐4  

页码: 315-321

 

ISSN:0367-8377

 

年代: 1992

 

DOI:10.1111/j.1399-3011.1992.tb00307.x

 

出版商: Blackwell Publishing Ltd

 

关键词: fragment coupling;mixed phosphinic anhydrides;1‐oxo‐l‐chlorophospholane;31P NMR;solid phase;solution phase

 

数据来源: WILEY

 

摘要:

The application of 1‐oxo‐l‐chlorophospholane as a novel reagent for thein situactivation of peptide fragments for use in peptide bond forming reactions, either in liquid or solid phase, has been examined. 24.1 MHz31P NMR spectroscopy has been employed to follow the formation, stability and reactivity of the intermediate phospholanic‐carboxylic mixed a

 

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