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Study of the Interaction Between Trypanocide 3-Nitrobenzaldehyde Guanyl Hydrazone and Bovine Serum Albumin by Equilibrium Dialysis and Nmr

 

作者: LuzineideWanderley Tinoco,   JoséDaniel Figueroa-Villar,  

 

期刊: Spectroscopy Letters  （Taylor Available online 1999）
卷期: Volume 32, issue 6  

页码: 941-951

 

ISSN:0038-7010

 

年代: 1999

 

DOI:10.1080/00387019909350039

 

出版商: Taylor & Francis Group

 

关键词: 3-nitrobenzaldehyde guanyl hydrazone;Equilibrium dialysis;NMR spin-lattice relaxation time.

 

数据来源: Taylor

 

摘要:

Equilibrium dialysis and NMR spin-lattice relaxation time (T1) studies of the interaction of the trypanocidal drug 3-nitrobenzaldehyde guanyl hydrazone (3NBGH) with bovine serum albumin (BSA) were used to show that this interaction is weak and nonspecific, making 3NBGH a potential agent for the prophylaxis ofTrypanosoma cruziinfected blood.

 

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