Ultrastructural Characteristics of Keloid Fibroblasts
作者:
Lois Matsuoka,
Jouni Uitto,
Jacobo Wortsman,
R. Abergel,
John Dietrich,
期刊:
The American Journal of Dermatopathology
(OVID Available online 1988)
卷期:
Volume 10,
issue 6
页码: 505-508
ISSN:0193-1091
年代: 1988
出版商: OVID
关键词: Fibroblasts;Keloids;Myofibroblasts
数据来源: OVID
摘要:
Myofibroblasts abound in granulation tissue, where they play an important role in the healing process. We evaluated the characteristics of fibroblasts in ten patients with keloids, a disorder of skin wound repair. Keloid lesions uniformly exhibited numerous fibroblasts with prominent Golgi complexes and abundant rough endoplasmic reticulum. Although rare fibroblasts exhibited a convoluted nucleus and tangled microfilaments, none could be characterized as myofibroblast, as defined by cytoplasmic myofilaments and cell to cell junctions. We conclude that fibroblast density and activity are increased in keloids, but true myofibroblasts are not a component of these lesions.
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