▴ Sertindole is a novel and atypical antipsychotic compound.▴ The drug selectively inhibits limbic dopamine function and is notable for its highin vitroaffinity for dopamine D2receptors, serotonin 5-HT2receptors and &agr;1-adrenergic receptors.▴ Sertindole shows marked antipsychotic activity in various animal models while lacking marked cataleptogenic, anticholinergic and autonomic activity.▴ Results of phase II and III clinical studies have shown sertindole to be effective in alleviating the positive and negative symptoms of schizophrenia.▴ Sertindole was not associated with disturbed motor function (including extrapyramidal symptoms) in phase II and III clinical studies.