Quantitative Genetics of Dehydroepiandrosterone Sulfate and Its Relation to Possible Cardiovascular Disease Risk Factors in Mexican Americans
作者:
C.E. Jaquish,
J. Blangero,
S.M. Haffner,
M.P. Stern,
J.W. Maccluer,
期刊:
Human Heredity
(Karger Available online 1996)
卷期:
Volume 46,
issue 6
页码: 301-309
ISSN:0001-5652
年代: 1996
DOI:10.1159/000154368
出版商: S. Karger AG
关键词: Dehydroepiandrosterone sulfate;Adrenal steroids;Lipoproteins;high density
数据来源: Karger
摘要:
Dehydroepiandrosterone sulfate (DHEAS) is an adrenal steroid which has been inversely associated with development of atherosclerosis. We estimated heritability of serum DHEAS levels in 564 related Mexican Americans. We found a significant heritability for DHEAS (h2 = 0.39, p < 0.001). Measures of alcohol consumption, reproductive status, body composition, and HDL3 levels showed significant relationships with serum DHEAS levels. Sex and age were significantly associated with the mean, but not the genetic variance, of DHEAS levels. The results of this study demonstrate a significant genetic influence on steroid concentration and help to quantify the factors contributing to cardiovascular disease risk in Mexican Americans.
点击下载:
PDF
(1523KB)
返 回