Mitotic index and Alzheimer's disease
作者:
Edmund Jenkins,
Lingling Ye,
Hong Gu,
Henryk Wisniewski,
期刊:
NeuroReport
(OVID Available online 1998)
卷期:
Volume 9,
issue 17
页码: 3857-3861
ISSN:0959-4965
年代: 1998
出版商: OVID
关键词: Alzheimer's disease;Colcemid inhibition;Mitotic index;Skin fibroblast cultures
数据来源: OVID
摘要:
ALZHEIMER'S disease (AD), a progressive neurodegenerative disorder, is diagnosed definitively by increased numbers of β-amyloid plaques and neurofibrillary tangles in brain biopsy or autopsy specimens. There are no simple straightforward laboratory tests currently available for clinical diagnosis. We have found consistent reduction in mitotic index levels in skin fibroblast cultures from AD individuals compared with age-and sex-matched controls. These differences were enhanced by overnight exposure to colcemid (p= 0.04). Results suggest that mitotic index in skin fibroblasts cultures should be further investigated as a potential diagnostic indicator for AD.
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