Chicken osteoclasts do not possess calcitonin receptors
作者:
G.C. Nicholson,
J.M. Moseley,
P.M. Sexton,
T.J. Martin,
期刊:
Journal of Bone and Mineral Research
(WILEY Available online 1987)
卷期:
Volume 2,
issue 1
页码: 53-59
ISSN:0884-0431
年代: 1987
DOI:10.1002/jbmr.5650020109
出版商: John Wiley and Sons and The American Society for Bone and Mineral Research (ASBMR)
数据来源: WILEY
摘要:
AbstractOsteoclasts freshly isolated from embryonic chicks have been examined for calcitonin receptors using radio‐iodine‐labeled salmon calcitonin. Calcitonin binding to chick osteoclasts could not be shown by either autoradiography or biochemical binding studies. Furthermore, calcitonin did not stimulate cyclic AMP production. By contrast, rat osteoclasts have abundant calcitonin receptors, and a sensitive cyclic AMP response to calcitonin has been shown previously. It is concluded that chick osteoclasts do not possess calcitonin receptors, a finding which could explain the lack of calcitonin responsiveness observed in other avian osteoclast culture syst
点击下载:
PDF
(2484KB)
返 回