Bartter’s Syndrome – A Dilemma of Cause and Effect
作者:
Edmund Bourke,
Vera Delaney,
期刊:
Nephron
(Karger Available online 1981)
卷期:
Volume 27,
issue 4-5
页码: 177-186
ISSN:1660-8151
年代: 1981
DOI:10.1159/000182051
出版商: S. Karger AG
关键词: Bartter’s syndrome;Urinary prostaglandins;Hypokalemia
数据来源: Karger
摘要:
Six interrelated abnormalities of Bartter’s syndrome are analyzed – juxtaglomerular hyperplasia, angiotensin resistance, altered kallikrein-kinin system, hyperprostaglandinuria, hypokalemia, and chloride-losing nephropathy. Arguments are advanced that any one of these could be the proximate cause and result in all the others. By the same token, each abnormality could be a consequence of any of the others and, furthermore, modulate the others by negative or positive feedback. Despite many recent insights, available data do not permit a definitive conclusion as to the locus of the primary abnormality. Rather, the syndrome presents as a remarkable biological counterpart to an electronic integrated circuit. The altered physiology of Bartter’s syndrome is reviewed and the pathogenesis of the syndrome analyzed in the light of recent liter
点击下载:
PDF
(2130KB)
返 回