Estrous Cycle Variations in Cholecystokinin and Substance P Concentrations in Discrete Areas of the Rat Brain
作者:
Maya Frankfurt,
Richard A. Siegel,
Ida Sim,
Wolfgang Wuttke,
期刊:
Neuroendocrinology
(Karger Available online 1986)
卷期:
Volume 42,
issue 3
页码: 226-231
ISSN:0028-3835
年代: 1986
DOI:10.1159/000124444
出版商: S. Karger AG
关键词: Rat;Cholecystokinin;Substance P;Estrous cycle;Amygdala- Septum;Preoptic area
数据来源: Karger
摘要:
Cholecystokinin (CCK) and substance P (SP) were measured in discrete areas of the rat brain at different stages of the estrous cycle. Significantly higher levels of CCK were found in the lateral septum during diestrus as compared to proestrus. In the parietal cortex, CCK concentrations were significantly higher in diestrus than in proestrus. In the amygdala, estrous levels of CCK were significantly higher than proestrous levels. SP concentrations were significantly higher in diestrus than in proestrus in the medial and lateral septum, and the medial and lateral preoptic area. In the amygdala and ventral tegmental area, SP concentrations were significantly higher in estrus than in proestrus. These data suggest that certain CCK and SP neuronal systems may play a role in regulating the hypothalamo-pituitary-gonadal axis and/or be involved in steroid-dependent behavior.
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