Biopharmaceutical characteristics of a new propranolol/ hydrochlorothiazide tablet combination
作者:
M. Kraml,
J. Dubuc,
D. Dvornik,
S. Patterson‐Kreuscherv,
H. Perdue,
T. Y. Lee,
J. Mullane,
期刊:
Biopharmaceutics&Drug Disposition
(WILEY Available online 1982)
卷期:
Volume 3,
issue 1
页码: 55-65
ISSN:0142-2782
年代: 1982
DOI:10.1002/bdd.2510030108
出版商: John Wiley&Sons, Ltd.
关键词: Bioavailability;Propranolol;Hydrochlorothiazide;Human;Interaction;Dog
数据来源: WILEY
摘要:
AbstractExperiments have been carried out in dogs and man to determine the effect of hydrochlorothiazide (HCT) on the pharmacokinetics of propranlol and to evaluate the bioavailability of two dosage forms containing both propranolol and HCT (40/25 and 80/25 mg, respectively). In adult male beagles, 50 mg of HCT had no apparent effect on AUC, Cmax,Tmax, andT1/2of propranolol administered concurrently. In man, INDERIDE® (40/25 mg) and INDERIDE® (80/25 mg) were shown to be similar in bioavailability to the reference formulations, i.e. the same amount of drugs administered as the separate tablets of INDERAL® plus HYDRODIURI
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