Left Ventricular Adaptation to Sustained Pressure Overload in the Conscious Dog
作者:
Bertrand Crozatier,
Dominique Caillet,
Olivier Bical,
Monique Laplace,
期刊:
Circulation Research
(OVID Available online 1984)
卷期:
Volume 54,
issue 1
页码: 21-29
ISSN:0009-7330
年代: 1984
出版商: OVID
关键词: Pressure overload;Ventricular function;In tropic state;Conscious animal
数据来源: OVID
摘要:
The early adaptation to aortic stenosis was studied in eight conscious dogs previously instrumented with a left ventricular micromanometer and ultrasonic crystals measuring left ventricular minor equator, left ventricular major axis, and ventricular wall thickness. Data were compared during control, acute inflation of a supravalvular aortic cuff occluder and 24 hours after aortic stenosis with and without β-blockade. Acute aortic stenosis increased peak systolic pressure and end-systolic pressure with a decrease of percent systolic shortening of minor diameter (%±L). Twenty-four hours after aortic constriction for heart rates, end-diastolic dimensions, and systolic pressures similar to those measured during acute aortic stenosis, %±L was significantly increased, compared with acute aortic constriction, and was close to control values. End-systolic diameter was not significantly different from control during sustained pressure overload, although end-systolic stress was increased by 26.7 ± 6.1% (P ± 0.01 with control), representing a leftward shift of the end-systolic stress-diameter relation. Similar results were obtained under β-blockade. We conclude that there is, in this model of moderate pressure overload, a nonsympathetic increased inotropic state very early after aortic constriction.
点击下载:
PDF
(1519KB)
返 回