Serum Levels of Intercellular Adhesion Molecule 1 in Patients with HIV‐Related Kaposi's Sarcoma
作者:
P. De Paoli,
C. Caffau,
M. D'Andrea,
M. Tavio,
U. Tirelli,
G. Santini,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 7
页码: 695-699
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: HIV;Intercellular adhesion molecule 1;Kaposi's sarcoma;CD4 lymphocytes.
数据来源: OVID
摘要:
Summary:Infection with the human immunodeficiency virus type 1 (HIV-1) in man is associated with an increase in the incidence of Kaposi's sarcoma (KS). The biological and clinical characteristics of these patients differ from those of subjects with other HIV-associated diseases. Here we report that levels of serum-soluble intercellular adhesion molecule 1 (sICAM 1) are increased in HIV-1-positive patients with KS, but not in patients belonging to other CDC classification groups. KS patients with elevated levels of serum sICAM 1 had a significant lowering of CD4 cell counts during the follow-up period compared with those KS subjects whose sICAM 1 levels were only moderately higher. We suggest that increased sICAM 1 levels may have a pathogenetic role in the development of HIV-associated immunodeficiency in KS patients and may also be considered an important prognostic factor.
点击下载:
PDF
(309KB)
返 回