Proliferative Response of CD4+and CD8+T Cell Subsets From Hispanics with HIV+and AIDSThe Superantigen Hypothesis
作者:
Edward Eylar,
Cynthia Rivera-Quiňones,
Harold Laroche,
Yasuhiro Yamamura,
期刊:
Journal of Acquired Immune Deficiency Syndromes
(OVID Available online 1994)
卷期:
Volume 7,
issue 2
页码: 124-128
ISSN:0894-9255
年代: 1994
出版商: OVID
关键词: Staphylococcal enterotoxins;Concanavalin A;OkT3 antibodies;Pokeweed mitogen;HIV;AIDS;Superantigen;Mitogen.
数据来源: OVID
摘要:
It has been hypothesized that the progressive deletion of CD4+T cells in the course of infection due to human immunodeficiency virus (HIV) may be mediated in part by interaction with a superantigen inherent in an HIV protein. Consequently, selective loss of CD4+cells with a T cell receptor Vβ-chain capable of interaction with superantigen would produce a CD4 population less or totally unresponsive to superantigen such as staphylococcal enterotoxins B and A (SHU and SEA respectively), but not to other mitogens such as concanavalin A. anti-CD3 (OKT3). or pokeweed mitogen. We tested this hypothesis by comparing the proliferative response of SEB and SEA with the other mitogens for 25 controls. 20 HIV+. and 15 donors with acquired immune deficiency syndrome (AIDS). We found that peripheral blood mononuclear cells, as well as the CD4+and CD8+subsets from both HIV+and AIDS sources, the degree of suppression of mitogenesis for SEB and SEA was approximately equal to or less than that of the other mitogens. Moreover. suppression of HIV+CD4+and CDS T cell responses to SEB and SEA was equal (26%). If HIV superantigens exist, our data suggest that they are not responsible for the selective depletion of the CD4+T cell subset as evaluated by SEB and SEA specificity.
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