Increased Pulse and Blood Pressure Associated withDesipramine Treatment of Bulimia Nervosa
作者:
B. WALSH,
COLLEEN HADIGAN,
LINDA WONG,
期刊:
Journal of Clinical Psychopharmacology
(OVID Available online 1992)
卷期:
Volume 12,
issue 3
页码: 163-168
ISSN:0271-0749
年代: 1992
出版商: OVID
数据来源: OVID
摘要:
The cardiovascular effects of desipramine were assessed in 74 young women with bulimia nervosa participating in a 6-week double-blind, placebocontrolled study. Desipramine treatment was associated with significant increases in pulse, reclining systolic and diastolic blood pressures, and orthostatic hypotension. These effects were clearly evident in the first week of treatment and remained relatively unchanged during the subsequent 5 weeks. The mean increases in reclining systolic and diastolic pressures were approximately 10 mm Hg. Data from 16 patients treated for an additional 2 months indicated that most of the effects of desipramine on blood pressure diminished over time, whereas the effects on pulse persisted. These results differ from the commonly expected cardiovascular effects of tricyclic antidepressants in adults. Evidence from the current study and from other reports suggests that the cardiovascular effects of tricyclic antidepressants are age-dependent.
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