POSSIBLE ORGANOPHOSPHATE‐INDUCED PARKINSONISM
作者:
KENNETH DAVIS,
JEROME YESAVAGE,
PHILIP BERGER,
期刊:
The Journal of Nervous and Mental Disease
(OVID Available online 1978)
卷期:
Volume 166,
issue 3
页码: 222-225
ISSN:0022-3018
年代: 1978
出版商: OVID
数据来源: OVID
摘要:
A case of possible organophosphate-induced parkinsonism is presented. The patient was a crop duster with numerous episodes of acute organophosphate intoxication and chronic organophosphate exposure. The etiology of parkinsonism is discussed in terms of a balance hypothesis between cholinergic and dopaminergic neurotransmission in the striatum. A possible relationship between chronic organophosphate exposure and alterations in central cholinergic or dopaminergic activity is suggested. The course of this patient raises the possibility that agricultural workers may be at risk for the late development of parkinsonism.
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