Biological effects of central nervous system stimulants
作者:
R. BRUCE HOLMAN,
期刊:
Addiction
(WILEY Available online 1994)
卷期:
Volume 89,
issue 11
页码: 1435-1441
ISSN:0965-2140
年代: 1994
DOI:10.1111/j.1360-0443.1994.tb03740.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
AbstractIn both animals and man, stimulants such as the amphetamines and cocaine are reinforcing and thus motivate repeated drug‐taking behaviour and leading to abuse. Although this class of drugs seems to act by different biological mechanisms in the central nervous system, it has been suggested that their action to increase dopaminergic neurotransmission is crucial to the reinforcing properties of these compounds. However, increasing evidence suggests that a number of other neurotransmitters/neuroregulators, possibly in conjunction with dopamine, are pan of the complex neurochemical systems which underlies various aspects of stimulant abuse behaviours. Examples of possible influences of noradrenaline and corticosterone will be discusse
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