Finite Element Analysis of Myocardial Diastolic Function Using Three‐Dimensional Echocardiographic ReconstructionsApplication of a New Method for Study of Acute Ischemia in Dogs
作者:
David McPherson,
David Skorton,
Srinivas Kodiyalam,
Lawrence Petree,
Michael Noel,
Robert Kieso,
Richard Kerber,
Steve Collins,
Krishnan Chandran,
期刊:
Circulation Research
(OVID Available online 1987)
卷期:
Volume 60,
issue 5
页码: 674-682
ISSN:0009-7330
年代: 1987
出版商: OVID
关键词: left ventricle;myocardium;diastolic properties;finite element analysis;3D reconstruction;echocardiography
数据来源: OVID
摘要:
The effect of acute myocardial ischemia on the myocardial elastic modulus has been a matter of controversy. To evaluate this question, diastolic elastic modulus was assessed by finite element analysis of left ventricular geometry using three-dimensional echocardiographic reconstructions and right and left ventricular pressure recordings. Elastic properties were estimated before and after coronary occlusion in 6 open-chest dogs. Elastic modulus values were derived by means of a computer program that determined the global elastic modulus that best predicted the diastolic changes in left ventricular geometry. In the finite element analysis after coronary occlusion, two analyses were performed: one utilizing the control elastic modulus for all segments of the left ventricle and one in which ischemic (dyskinetic) segments were assigned a higher elastic modulus. Results showed that the control elastic modulus was a poor predictor of diastolic left ventricular expansion after coronary occlusion. The finite element analysis in which the ischemic segments were assigned a higher elastic modulus better predicted ischemic diastolic wall motion patterns. Error values (difference between predicted and actual left ventricular segmental diastolic motion) were: control, 1.9 ± 0.3 mm (mean ± SD), ischemia, 2.9 ± 0.5 mm, and 2.2 ± 0.4 mm using the stiffer elastic modulus for ischemic segments. Error values were significantly higher (p< 0.05) under ischemic conditions when the control elastic modulus was uniformly applied compared with control and ischemia with dyskinetic segments assigned a higher elastic modulus. From these data, it is concluded that the myocardial diastolic elastic modulus is increased by ischemia and that this approach may allow clinical assessment of intrinsic muscle stiffness.
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