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Synthesis and Anti Tuberculostatic Activity of Novel 1,3,4‐Oxadiazole Derivatives

 

作者: M. Shahar Yar,   A. Ahmad Siddiqui,   M. Ashraf Ali,  

 

期刊: Journal of the Chinese Chemical Society  （WILEY Available online 2007）
卷期: Volume 54, issue 1  

页码: 5-8

 

ISSN:0009-4536

 

年代: 2007

 

DOI:10.1002/jccs.200700002

 

出版商: WILEY‐VCH Verlag

 

关键词: 1,3,4‐Oxadiazole;Antimycobacterial agents

 

数据来源: WILEY

 

摘要:

AbstractA series of novel 2,5‐disubstituted 1,3,4‐oxadiazole derivatives were synthesized and tested for theirin vitroantimycobacterial activity. Some compounds showed interesting activity against a strain ofMycobacterium tuberculosisH37Rv. The result of the antimycobacterial activity tests revealed that 2‐(2‐naphthyloxymethyl)‐5‐phenoxymethyl‐1,3,4‐oxadiazole (IVd) exhibited>90% inhibiti

 

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