New Morphological Approaches to the Study of Mitochondrial Encephalomyopathies
作者:
Eduardo Bonilla,
Monica Sciacco,
Kuranai Tanji,
Marco Sparaco,
Vittoria Petruzzella,
Carlos T. Moraes,
期刊:
Brain Pathology
(WILEY Available online 1992)
卷期:
Volume 2,
issue 2
页码: 113-119
ISSN:1015-6305
年代: 1992
DOI:10.1111/j.1750-3639.1992.tb00679.x
出版商: Blackwell Publishing Ltd
数据来源: WILEY
摘要:
Molecular genetics, biochemistry, immunology and morphology, are being applied in a coordinated fashion to unveil the molecular basis of the mitochondrial encephalomyopathies. Mutations of mitochondrial DNA (mtDNA) have been found in well characterized clinical groups of these disorders. New and old morphologic methods have been applied to investigate muscle biopsies from patients with mtDNA mutations. Important observations have been made on the cellular localization of normal and mutated mtDNA and on the expression of mtDNA‐encoded polypeptides. These observations have provided insight into the pathogenesis of respiratory chain enzyme deficiency at the level of individual muscle fibers. Application of immunocytochemical andin situhybridization techniques at the electron microscopic level will extend these studies to the level of individual mitochondri
点击下载:
PDF
(8017KB)
返 回