Tumor cell karyotypes in malignant melanoma
作者:
W. M. Henry,
M. S. Didolkar,
R. Lopez,
L. D. Tomei,
期刊:
Journal of Surgical Oncology
(WILEY Available online 1979)
卷期:
Volume 11,
issue 1
页码: 31-38
ISSN:0022-4790
年代: 1979
DOI:10.1002/jso.2930110107
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: melanoma;karyotypes;prognosis
数据来源: WILEY
摘要:
AbstractFifteen malignant melanomas were subjected to chromosomal analysis, in order to determine whether the number of chromosomes in a tumor cell could be correlated to a clinical prognosis. The protocol involved a direct technique which utilized a Colcemid blockade of spindle formation in mitosis to allow study of metaphase chromosomes. The direct method was chosen to reveal chromosome changes in the tumor cell in situ rather than changes in the cultured cell. Two tumors yielded chromosome spreads which could be counted and correlated with a clinical prognosis. Failure to obtain other adequate chromosome spreads were accounted for by the presence of tissue necrosis and the absence of viable tumor cells.
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