The role of high dose 67‐gallium scintigraphy in staging untreated patients with lymphoma
作者:
G. Larcos,
D. C. Farlow,
V. F. Antico,
S. M. Gruenewald,
J. Boyages,
期刊:
Australian and New Zealand Journal of Medicine
(WILEY Available online 1994)
卷期:
Volume 24,
issue 1
页码: 5-8
ISSN:0004-8291
年代: 1994
DOI:10.1111/j.1445-5994.1994.tb04417.x
出版商: Blackwell Publishing Ltd
关键词: Gallium‐67;radionuclide imaging;lymphoma
数据来源: WILEY
摘要:
Abstract:Background:Gallium‐67 (67Ga) scintigraphy has been reported to be of limited value in staging lymphoma patients. However, recent technical advances in radionuclide imaging have potentially enhanced the usefulness of this method.Aims:The purposes of this study were to determine the current: (1) sensitivity and specificity and (2) impact on clinicians' treatment decisions of67Ga scans performed at a teaching hospital.Methods:There were 46 newly presenting patients with lymphoma (13 with Hodgkin's disease (HD) and 33 with non‐Hodgkin's lymphoma [NHL]). Planar67Ga scans were performed up to eight days following injection of 300 MBq (8 mCi) with images interpreted by consensus of two blinded observers; sensitivity and specificity were determined on a lesion by lesion basis in comparison to computed tomography (CT) scans, palpation of peripheral lymph nodes and abdominal lymphangiograms (n = 5). The contribution of67Ga scans to clinicians' treatment decisions was also independently assessed by an experienced oncologist.Results:Gallium‐67 scan sensitivity and specificity were 80% and 96% for HD and 59% and 98% for NHL. Initial treatment plans were modified in three individuals (7%; 95% confidence intervals = 3–10%) due to lesions on the67Ga scan not prospectively detected or considered equivocal on other tests.Conclusions:Only a small proportion of newly diagnosed lymphoma patients benefit from staging with state of the art planar high dose67Ga
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