Corneal cell adhesion and proliferation on hydrogel sheets bound with cell-adhesive proteins
作者:
KobayashiHisatoshi,
IkaciaYoshito,
期刊:
Current Eye Research
(Taylor Available online 1991)
卷期:
Volume 10,
issue 10
页码: 899-908
ISSN:0271-3683
年代: 1991
DOI:10.3109/02713689109020325
出版商: Taylor&Francis
数据来源: Taylor
摘要:
The efficiency of protein immobilization to provide a hydrogel surface with a high affinity for corneal epithelial cells was investigated. The cell adhesive proteins collagen and fibronectin, and the cell adhesive oligopeptide RGDS(arginine-glycine-aspartic acid-serine) were successfully covalently immobilized on poly(vinyl alcohol)(PVA) hydrogel sheets. Corneal epithelial cells and L-929 cells were applied to these surfaces. A large number of cells did adhere and proliferate on these protein-bound surfaces in comparison with the virgin PVA not so immobilized.
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