Convulsive Effect of Theophylline in Conscious and Anaesthetized Guinea‐pigs
作者:
Carl G.A. Persson,
Ingrid Erjefält,
期刊:
Acta Pharmacologica et Toxicologica
(WILEY Available online 1981)
卷期:
Volume 48,
issue 1
页码: 32-38
ISSN:0001-6683
年代: 1981
DOI:10.1111/j.1600-0773.1981.tb01584.x
出版商: Blackwell Publishing Ltd
关键词: Theophylline;convulsions;guinea‐pig
数据来源: WILEY
摘要:
Abstract:In urethane‐anaesthetized guinea‐pigs, the effect of theophylline (theo) on heart rate, arterial blood pressure, respiration rate and limb movements were recorded. Continuous intravenous infusion of theo initially increased the respiratory and heart rates and lowered the arterial blood pressure. After infusion of about 50 mg/kg of theo, the cardiovascular effects reached a maximum and were then only slightly changed until the terminal stage. A tonic stretching of the limbs (at 155 ± 15 mg/kg) preceded generalized seizures of clonic tonic convulsions which were recorded after infusion of 367 ± 25 mg/kg of theo. At this stage, respiration was highly irregular. PaO2started to fall and PaCO2to rise, while a plasma acidosis developed rapidly. The convulsions progressed in frequency and intensity and were terminally associated with respiratory and cardiovascular collapse. The convulsive effects of theophylline were similar to those observed in conscious guinea‐pigs after 250 mg/kg of theo orally. The present findings agree with the view that the convulsive effect is a primary life‐threatening action of theophylline. The method described may be of use in the search for new, less toxic xanth
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