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Effect of Normal and Preeclamptic Pregnancies on the Oxyhemoglobin Dissociation Curve

 

作者: J. Kambam,   Robert Handte,   Walter Brown,   Bradley Smith,  

 

期刊: Anesthesiology  (OVID Available online 1986)
卷期: Volume 65, issue 4  

页码: 426-427

 

ISSN:0003-3022

 

年代: 1986

 

出版商: OVID

 

关键词: Measurement techniques: oxygen saturation;Oxygen: oxyhemoglobin dissociation;P-50;transport;Pregnancy: normal;preeclampsia

 

数据来源: OVID

 

摘要:

Hemoglobin affinity for oxygen in whole blood of ten normal nonpregnant women, ten normal pregnant women at first trimester, ten normal pregnant women at second trimester, 24 normal pregnant women at or near term, and 14 pregnant women with preeclampsia at or near term was studied. The mean P-50 values for normal non-pregnant women, normal pregnant women in first trimester, second trimester, and at or near term were 26.7 ± 0.11 mmHg, 27.8 ± 0.08 mmHg, 28.8 ± 0.17 mmHg, and 30.4 ± 0.20 mmHg, respectively. The mean P-50 of pregnant women with preeclampsia at or near term was 25.1 ± 0.38 mmHg. It is concluded that in normal pregnant women there was a significant shift of P-50 to the right compared with the normal nonpregnant women (P< 0.01), and the extent of this shift to the right is directly related to the duration of the pregnancy. In addition, preeclamptic parturients showed a significant shift of P-50 to the left when compared with normal pregnant women at or near term (P< 0.001).

 

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