Effect of Age on the Development of Cardiac Hypertrophy Produced by Aortic Constriction in the Rat
作者:
Shogen Isoyama,
Jeanne Wei,
Seigo Izumo,
Peter Fort,
Frederick Schoen,
William Grossman,
期刊:
Circulation Research
(OVID Available online 1987)
卷期:
Volume 61,
issue 3
页码: 337-345
ISSN:0009-7330
年代: 1987
出版商: OVID
关键词: left ventricular hypertrophy;adult aging;senescence;afterload;RNA
数据来源: OVID
摘要:
To test the hypothesis that the capacity ito develop left ventricular (LV) hypertrophy might diminish with advancing age, we examined the hypertrophic response to ascending aortic constriction in 3 groups of adult Fischer 344 rats (9 months, 18 months, and 22 months of age). Aortic constriction was created so that aortic cross-sectional areas would be the same for the 3 groups of rats. Four weeks after imposition of aortic constriction, there was no significant difference in peak LV pressure, peak-to-peak and mean systolic pressure gradients between left ventricle and aorta, cardiac output, LV minute work, or cross-sectional area of the aortic constrictions in the 3 groups. In 9-month-old aortic-constricted rats, LV dry wt (LVDW)/body wt, LVDW/tibial length, and myocyte width increased by 23% (p<0.01), 14% (p<0.01), and 27% (p<0.01), respectively, compared with sham-operated rats. In contrast, in 18-month-old and 22-month-old aortic-constricted rats, LVDW/body wt and LVDW/tibial length were unchanged compared with sham-operated controls, and increases in myocyte width were only modest 4 weeks following constriction. RNA concentration in the myocardium 5 days after constriction increased by 21 % (p<0.001) in 9-month-old rats but showed no significant rise in 18-month-old rats. These results suggest that advancing age is associated with a diminished capacity to develop myocardial hypertrophy in response to acute pressure overload and that a reduced ability to synthesize protein may be one of the major contributing factors to a diminished capacity for hypertrophy in advanced age.
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