Conductimetric, Potentiometric and Visual Titrimetric Methods for Analysis of Nadolol
作者:
MohamedE. Mohamed,
MoustafaS. Tawakkol,
EsamA. Lotfi,
HassanY. Aboul-enein,
期刊:
Analytical Letters
(Taylor Available online 1981)
卷期:
Volume 14,
issue 5
页码: 349-356
ISSN:0003-2719
年代: 1981
DOI:10.1080/00032718108081410
出版商: Taylor & Francis Group
关键词: Titrimetry;Pharmaceutical analysis;Assay of Nadolol tablets (Corgard(R))
数据来源: Taylor
摘要:
Nadolol, a beta-blocking agent, has been assayed in pure form and in pharmaceutical formulation by acidimetric titrations using visual, potentiometric and conductimetric methods for detecting the end point in aqueous as well as in non-aqueous media. The method of assay involves the determination of the amount of nadolol in a given weight of sample. Six samples were run for each method and the percentages of recovery of nadolol from its tablets were calculated. For aqueous titrations, the average percentages of recovery for the visual, potentiometric and conductimetric methods are 100.6 ± 1.0, 99.3 ± 1.9 and 100.1 ± 2.0 respectively. For the non-aqueous titrations, the average percentages of recovery are 98.6 ± 0.8, 99.5 ± 0.5 and 98.4 ± 1.3 for the visual, potentiometric and conductimetric methods respectively.
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