Retinal neurons lack an acetylcholine receptor aggregating factor
作者:
Jeffrey M. Thompson,
Stanley I. Rapoport,
期刊:
Synapse
(WILEY Available online 1988)
卷期:
Volume 2,
issue 1
页码: 7-10
ISSN:0887-4476
年代: 1988
DOI:10.1002/syn.890020103
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: Synapse;Stabilization;Trophic;Muscle;Spinal cord;Tissue culture
数据来源: WILEY
摘要:
AbstractSpinal cord neurons form stable synapses on muscle cells in culture, whereas retinal neurons, an inappropriate presynaptic partner for muscle cells, form synapses that are transient. We have hypothesized that a trophic influence of neurons on muscle is involved in the stabilization of synapses. Because other neural tissues that form stable synapses on muscle cells contain factors that aggregate acetylcholine receptors (AChR) into clusters on the surface of muscle cells. It may be that these aggregation factors are necessary for stabilization of neuron‐muscle synapses. Therefore, we determined the AChR‐aggregating activity of retinal neurons. The results showed that cocultures of retinal neurons and muscle cells and retinal‐conditioned medium do not show increases in the number of AChR on muscle cells. Conversely, spinal cord‐muscle cocultures and spinal cord‐conditioned medium produce increases in the number of AChR clusters. These data, along with previous studies demonstrating that retinal neurons are unable to affect the electrical membrane properties of cultured muscle cells, whereas spinal cord neurons do elicit such changes, add support to the above hypothesis of a trophic influence of neurons in synapse stab
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