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Trisomy 2 as the sole chromosomal abnormality in a hepatoblastoma

 

作者: Georgia Bardi,   Bertil Johansson,   Nikos Pandis,   Sverre Heim,   Nils Mandahl,   Felix Mitelman,   Albert Békássy,   Inga Hägerstrand,  

 

期刊: Genes, Chromosomes and Cancer  （WILEY Available online 1992）
卷期: Volume 4, issue 1  

页码: 78-80

 

ISSN:1045-2257

 

年代: 1992

 

DOI:10.1002/gcc.2870040111

 

出版商: Wiley Subscription Services, Inc., A Wiley Company

 

数据来源: WILEY

 

摘要:

AbstractShort‐term cultures of a fine‐needle aspirate from a hepatoblastoma were analyzed cytogenetically. Trisomy 2 was found as the sole abnormality, yielding the karyotype 47,XY, + 2/46,XY. Because trisomy for all or part of chromosome 2 has been described, although together with other aberrations, in seven of the 11 hepatoblastomas hitherto reported, the finding of +2 as the only anomaly in the present case strongly indicates that additional chromosome 2 material is of pathogenetic significance in this tumor t

 

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