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Transcripts, Transcripts, EverywhereOn: Malignant peripheral nerve sheath tumors with t(X;18). A pathologic and molecular genetic study. O'Sullivan MJ, Kyriakos M, Zhu X, et al.Mod Pathol2000;13:1253–63On: Identification of EWS/FLI-1 transcript in giant-cell tumor of bone. Scotlandi K, Chano T, Benini S, et al.Int J Cancer2000;87:328–35

 

作者: Enrique de Alava,  

 

期刊: Advances in Anatomic Pathology  （OVID Available online 2001）
卷期: Volume 8, issue 5  

页码: 264-272

 

ISSN:1072-4109

 

年代: 2001

 

出版商: OVID

 

关键词: Translocation;Gene fusion;Reverse transcription polymerase chain reaction;Fluorescence in situ hybridization;Synovial sarcoma;Malignant peripheral sheath tumor

 

数据来源: OVID

 

摘要:

A typical feature of many sarcomas is the consistent presence of balanced chromosomal translocations, originating novel gene fusions. Two recent reports show gene fusions with reverse transcription polymerase chain reaction in two unexpected entities: EWS-FLI-1 in giant cell tumor of bone and SYT-SSX in malignant peripheral nerve sheath tumor. This commentary discusses several items that can be of help in performing a critical evaluation of these reports and similar ones.

 

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