The effects of intravenous prostacyclin in a model of microsurgical thrombosis
作者:
Julian E. Bailes,
Matthew R. Quigley,
Hau C. Kwaan,
Bing R. Nishiura,
Leonard J. Cerullo,
Clara Lastre,
期刊:
Microsurgery
(WILEY Available online 1988)
卷期:
Volume 9,
issue 1
页码: 2-9
ISSN:0738-1085
年代: 1988
DOI:10.1002/micr.1920090103
出版商: Wiley Subscription Services, Inc., A Wiley Company
数据来源: WILEY
摘要:
AbstractNumerous agents have been administered in an attempt to achieve specific biochemical antiplatelet activity. A model of microsurgical trauma was utilized to create a nonocclusive thrombus, similar to what occurs in the postoperative period. Prostacyclin (PGI2) was given in a high intravenous dose which caused in vitro inhibition of platelet aggregation in rats and rabbits. Although hematological and cardiovascular side effects of PGI2were tolerated, in vivo platelet thrombus formation persisted and constituted 25–75% of the postoperative thrombus. Even though platelets were inhibited by PGI2, other significant stimuli remained at the site of injury for activation and participation of platelets in the formation of a thrombu
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