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Application of Neural Networks in the QSAR Analysis of Percent Effect Biological Data: Comparison with Adaptive Least Squares and Nonlinear Regression Analysis

 

作者: M. Wiese,   K.-J. Schaper,  

 

期刊: SAR and QSAR in Environmental Research  (Taylor Available online 1993)
卷期: Volume 1, issue 2-3  

页码: 137-152

 

ISSN:1062-936X

 

年代: 1993

 

DOI:10.1080/10629369308028825

 

出版商: Taylor & Francis Group

 

关键词: artificial neural network;QSAR;percent effect;adaptive least squares;nonlinear regression

 

数据来源: Taylor

 

摘要:

Artificial neural networks (ANN) can be used for the direct QSAR analysis of percent effect biological data, thus avoiding the bias introduced by arbitrarily chosen classes and the loss of information due to prior classification. For two data sets the ANN results are compared with those obtained by adaptive least squares and nonlinear regression analyses. In comparison with the other methods the neural network shows higher predictive power and does not require an explicit equation relating the observed effect to physico-chemical descriptors.

 

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