On the basis of the criteria of the California Dental Association (CDA), 66 CAD/CAM-manufactured ceramic class-II inlays (Cerec) were compared intraindividually after they had been cemented with either a chemically cured or a dual-cured composite resin luting agent in 27 patients. Plaque and gingival conditions, the overall time consumption for producing each inlay, and the frequency of postoperative sensitivity were also evaluated. There was no statistically significant difference between the two luting agents with regard to the properties evaluated. One inlay was replaced owing to fracture of the restored tooth just before the 24-month re-examination. After 2 years excellent CDA ratings were obtained for color in 92% of the remaining 65 inlays. The corresponding figures for surface and for anatomic form were 100% and 85%, respectively. For margin integrity 85% of the 33 inlays cemented with the dual-cured luting agent and 88% of the 33 inlays cemented with the chemically cured luting agent were rated excellent after 2 years.